Infectious mononucleosis
Causes are EBV, CMV, Adenovirus, HIV, Hepatitis A.
Presents with fever, fatigue, sore throat, tonsillar exudates and posterior cervical lymphadenopathy.
Diagnosis:-
1. Monospot test detects heterophile antibodies.
2. CBC shows lymphocytosis (i.e. atypical lymphocytosis); Atypical lymphocytes are reactive CD8+ T cells.
3. Serologic detects EBV viral capsid antigen.
1. Monospot test detects heterophile antibodies.
2. CBC shows lymphocytosis (i.e. atypical lymphocytosis); Atypical lymphocytes are reactive CD8+ T cells.
3. Serologic detects EBV viral capsid antigen.
Management:-
1. Supportive measures like bed rest, fluids and antipyretics.
2. Avoid contact sports for one month as it increases risk for splenic rupture.
3. Avid amoxicillin as it causes generalized maculopapular rash in patients with infectious mononucleosis.
1. Supportive measures like bed rest, fluids and antipyretics.
2. Avoid contact sports for one month as it increases risk for splenic rupture.
3. Avid amoxicillin as it causes generalized maculopapular rash in patients with infectious mononucleosis.
Complications:-
1. Burkitt’s lymphoma
2. Nasopharyngeal carcinoma
3. Primary CNS lymphoma
1. Burkitt’s lymphoma
2. Nasopharyngeal carcinoma
3. Primary CNS lymphoma
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