Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm predominantly composed of proliferating granulocytes and has the Philadelphia chromosome/translocation t(9;22). Philadelphia chromosome results from translation of ABL-1 gene from chromosome 9 to breakpoint cluster region (BCR) on chromosome 22 i.e. t(9;22); BCR-ABL codes an oncogenic protein with increased tyrosine kinase activity.
Presents with fever, fatigue, weight loss and splenomegaly.
Diagnosis:-
1. CBC
2. F.I.S.H shows philadelphia chromosome.
3. PCR
1. CBC
2. F.I.S.H shows philadelphia chromosome.
3. PCR
Treatment:-
1. Imatinib (tyrosine kinase inhibitors).
2. Allogeneic hematopoietic stem cell transplant.
1. Imatinib (tyrosine kinase inhibitors).
2. Allogeneic hematopoietic stem cell transplant.
No comments:
Post a Comment